Brian Yu

Researcher

Brian studies the conjecture of the Rho-kinase pathway and its potential mediatory actions on cardiovascular disease (CVD) and diabetes. In particular, diabetics are a group with elevated risk for CVD, such as diminished diastolic function, greater cardiac mass,  and higher chance for coronary artery disease, and are an emerging group in cardiology clinics that may require therapy relative to CV risk.

On the clinical side, Brian is also working on studying how longitudinal movement of the myocardium, quantified through an emerging echocardiography technique called global longitudinal strain (GLS), relates with various diastolic and systolic parameters.

Brian is also interested in health outcomes research, particularly how cardiovascular outcomes are affected by changes in hospital safety attitudes, novel clinical standards, and accreditation processes,

Phone number: (773) 702-5897 | E-mail: briyu@uchicago.edu | Google Scholar Profile.

Peer-reviewed Publications

1. Sladojevic N., Yu B., Liao JK (2017). “ROCK as a Therapeutic Target for Ischemic Stroke.” Expert Rev Neurother. doi: 10.1080/14737175.2017.1395700. PMID: PMC6221831.

2. Shimizu T., Narang N., Chen P., Yu B., Knapp M., Janardanan, J., Blair JE., Liao JK (2017) “Fibroblast ROCK2 as a Critical Mediator of Cardiac Hypertrophy, Fibrosis, and Heart Failure with Preserved Ejection Fraction.” JCI Insight. doi: 10.1172/jci.insight.93187. PMID: PMC5499369.

3. Yu B., Sladjoevic N., Blair JE., Liao JK (2020). “Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening.” Expert Opp Ther Tar. doi: 10.1080/14728222.2020.1712593. PMID: 31906742.

4. Yu B., Wen CF., Lo HL., Liao HH., Wang PC. (2020). “Improvements in patient safety culture: a national Taiwanese survey, 2009-16.” Int J Qual Health Care. doi: 10.1093/intqhc/mzz099.  PMID: 31917449.

Awards

Berkeley Haas Go to Market Venture Capitalist Competition, Finalist, Audience’s Choice, 2018

KY-ACC 2nd Place Award for Excellence in Cardiology Research Presentation, 2017

College New Venture Challenge (CNVC) Semifinalist, 2017