Welcome to the Cardiovascular Research Laboratory
CVRL specializes in research in a multi-disciplinary and translational approach to cardiovascular disease and vascular biology. Our laboratory studies the Rho/Rho-kinase signalling pathway, the regulation of angiogenesis in ischemic tissue, and the conjecture of metabolic disease and cardiovascular homeostasis.
Nik working on his presentation.
CVRL values: hard work, independence, and honesty in scientific research.
Recent NEWS
Final Presentation and Farewell for Henry
Today, Henry Utset, our this year's PSOMER student, gave his final laboratory presentation on correlations between Rho kinase activity and various strain parameters. We had a fun time getting to know Henry over the past month, and we wish him the best when he applies...
Welcome Dongbo!
We welcome Dongbo Yu, MD, PhD, to the laboratory as part of the Physician Scientist Training Program (PSTP). His project is regarding exosomes in the cardiovascular system. We look forward to working with Dongbo in the years to come.
Welcome Xiaoxiang!
Today Xiaoxiang Ma, a visiting scholar from Chengdu, China, will be joining our laboratory for the next year. She was a practicing cardiologist in China and plans to do work at the Cardiovascular Research Laboratory translating basic science discoveries to the...
Recent Publications
Yu B, Sladojevic N, Blair JE, Liao JK. Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening. Expert Opp Ther Tar.
Abstract: Introduction: Pathological cardiac fibrosis, through excessive extracellular matrix protein deposition from fibroblasts and pro-fibrotic immune responses and vascular stiffening is associated with most forms of cardiovascular disease. Pathological cardiac...
Hiroi Y, Noma K, Kim HH, Sladojevic N, Tabit CE, Li Y, Soydan G, Salomone S, Moskowitz MA, Liao JK. Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice. Circ J.
Abstract: BACKGROUND: Rho-associated kinases (ROCK1 and ROCK2) are important regulators of the actin cytoskeleton and endothelial nitric oxide synthase (eNOS). Because the phosphorylation of eukaryotic elongation factor-1A1 (eEF1A1) by ROCK2 is critical for eNOS...
2018 CVRL Abstract Listing
The following abstracts will be presented by the following CVRL members in 2018: Nikola Sladojevic will present “Novel strategy to protect blood brain barrier integrity by modulating RGS5 in ischemic stroke" at the International Stroke Conference in LA, January 24-26....