by Brian | Jan 16, 2020 | Publication, Review
Abstract: Introduction: Pathological cardiac fibrosis, through excessive extracellular matrix protein deposition from fibroblasts and pro-fibrotic immune responses and vascular stiffening is associated with most forms of cardiovascular disease. Pathological cardiac...
by Brian | Jan 18, 2018 | Article, Publication
Abstract: BACKGROUND: Rho-associated kinases (ROCK1 and ROCK2) are important regulators of the actin cytoskeleton and endothelial nitric oxide synthase (eNOS). Because the phosphorylation of eukaryotic elongation factor-1A1 (eEF1A1) by ROCK2 is critical for eNOS...
by Brian | Jan 13, 2018 | Abstracts, Publication
The following abstracts will be presented by the following CVRL members in 2018: Nikola Sladojevic will present “Novel strategy to protect blood brain barrier integrity by modulating RGS5 in ischemic stroke” at the International Stroke Conference in LA, January...
by Brian | Nov 10, 2017 | Publication, Review
Abstract: Introduction: Stroke is a major cause of disability and the fifth leading cause of death. Currently, the only approved acute medical treatment of ischemic stroke is tissue plasminogen activator (tPA), but its effectiveness is greatly predicated upon early...
by Brian | Jul 6, 2017 | Article, Publication
Abstract: Although left ventricular (LV) diastolic dysfunction is often associated with hypertension, little is known regarding its underlying pathophysiological mechanism. Here, we show that the actin cytoskeletal regulator, Rho-associated coiled-coil containing...
by Brian | Jun 8, 2017 | Article, Publication
Abstract BACKGROUND: Non-surgical bleeding (NSB) due to angiodysplasia is common in left ventricular assist device (LVAD) patients. Thrombin-induced angiopoietin-2 (Ang-2) expression in LVAD patients leads to altered angiogenesis and is associated with lower...
